Essentially, any disorder that causes enlargement of the spleen (splenomegaly) can cause hypersplenism. That’s because as your spleen becomes enlarged, it holds more and more blood cells. This includes damaged and healthy blood cells. This stops your healthy blood cells from circulating and allowing your body to perform its functions and fight disease.
Conditions that can lead to an enlarged spleen and, thus, hypersplenism are:
- Chronic liver diseases. These include hepatitis C, which causes inflammation of your liver, and cirrhosis, a liver disease in which scar tissue takes over healthy liver tissue. Cirrhosis caused by consuming too much alcohol as well as nonalcoholic cirrhosis can both cause hypersplenism.
- Infections. This includes malaria, a flu-like illness carried by mosquitos, and tuberculosis, a bacterial lung disease.
- Autoimmune diseases. These conditions, such as lupus and rheumatoid arthritis, cause widespread inflammation.
- Gaucher disease. This inherited disease causes fats to build up in your spleen.
- Cancer. One type of cancer that may cause enlargement is lymphoma, a cancer of your lymphatic system, which includes your spleen.